Update so far:
I emailed Saffron's sister Camille Henderson a while back as there is no way to contact Saffron directly as her official site was taken down due to no longer paying the hosting, and her Twitter has been abandoned for about a year now. Camille said she forwarded my question to her but I don't think i'm going to hear anything back. I first emailed her on March 27 and the last time I spoke to her was on April 13 to check if Saffron received the forwarding where she basically said "Saffron's super busy right now and i'll forward this email to follow up". If she was going to respond she would have done it by now I feel, no one's that busy. It would have been nice if she could have just politely replied with a no but whatever hey.
Plus it's known that Saffron has no love for the franchise or the character at all. She hasn't appeared in any of the documentaries or attended any of the conventions (Though she still attends Anime conventions). Still you'd think she'd like being a playable character in a game. She has done voice work in video games before such as Saints Row 1 and 2, The Sopranos: Road To Respect, The Punisher etc. on PS2.
The only time I could find her ever mentioning it in an interview was one from 1996 in Rumic World where she stated: ‘I have a tendency to get killed at the beginning of films [LAUGHS], and it happened again! There was a "Jason"- I'm not gonna say which Friday the 13th, 'cause I really don't want anyone to know- but I was a rock guitar player, and Jason took my guitar from me and I got killed with a guitar in the head. Right at the beginning of the film! [CHOCKED SOB] It just keeps happening!’ (the "again" referring to her being killed in the first 5 minutes of The Fly II as well).
That underlined part clearly shows how she feels about the film though it was a very old interview almost as old as me so she may have warmed to the film a bit more now. She did respond to someone on Twitter (back when her profile still had activity) about it but it was mainly talking about her hair and how it doesn't normally have that much volume. Maybe she'll email back saying she's down for lending her likeness and voice for the game but it's not looking promising right now. But I have done all I possibly can to try and make it happen so far.